TP63 and head and neck squamous cell carcinoma: Consistent with the oncogenic roles of YAP1 reported in OSCC (Hiemer et al., 2015; Omori et al., 2020), another study showed that p63, together with the co-expressing chromotin remodeling factor, ACTL6A, can drive YAP1 activation, suppressing differentiation and promoting cell proliferation in HNSCC (Saladi et al., 2017).