From the 918 genes, 45 genes fall into the tractability group 1, some examples of genes in this group include EGFR, PIK3CA, CDK4, and CDK6, where anticancer drugs targeting these genes are already approved or clinical trials for the treatment of HNSCC are on-going, demonstrating the robustness of our results. Here, EGFR is linked to head and neck squamous cell carcinoma.