WWTR1 and neoplasm: The inactivation of the Hippo pathway through the loss of LATS1/2 was reported to cause the induction of anti-tumor immune response and inhibition of HNSCC tumor growth, via the hyperactivation of YAP1/WWTR1 (Barth et al., 2013; Moroishi et al., 2016). This demonstrates that components of the Hippo signaling pathway could also modulate the host tumor microenvironment in addition to what we have demonstrsated in cancer cells.