The inactivation of the Hippo pathway through the loss of LATS1/2 was reported to cause the induction of anti-tumor immune response and inhibition of HNSCC tumor growth, via the hyperactivation of YAP1/WWTR1 (Barth et al., 2013; Moroishi et al., 2016). This demonstrates that components of the Hippo signaling pathway could also modulate the host tumor microenvironment in addition to what we have demonstrsated in cancer cells. This evidence concerns the gene YAP1 and neoplasm.