On the other hand, BICR10 harbors an inactivating mutation on KEAP1 (R320Q) a negative regulator of NFE2L2. The R320Q mutation has been reported to stabilize NRF2 (encoded by NFE2L2) and enhances cell fitness as reported previously in lung cancer (Hast et al., 2014). Here, KEAP1 is linked to lung cancer.