Emerging evidence demonstrate that YAP1 and WWTR1 have distinct roles where they partner with different transcription factors, drive different downstream effectors and also modulate the tumor microenvironment distinctively (Callus et al., 2019; Janse van Rensburg et al., 2018; Kaan et al., 2017; Plouffe et al., 2018). The gene discussed is YAP1; the disease is neoplasm.