To explore the mechanism among miR-203, CAV1, and the PI3K/AKT signaling pathway in RCC, RT-qPCR and western blot analysis were conducted to detect miR-203, CAV1, PI3K, AKT, β-catenin, N-cadherin, bcl-2, E-cadherin, and Bax expression. This evidence concerns the gene CDH2 and renal cell carcinoma.