We further provide several lines of evidence showing the important role of ndufa7 in cardiac hypertrophy: Knockdown of ndufa7 leads to cardiac defect in developing zebrafish embryos; ndufa7 depletion contributes to the elevated expression of hypertrophic biomarkers nppb and nppa; calcineurin signalling is involved in ndufa7 inhibition induced cardiac hypertrophy. The gene discussed is NPPB; the disease is cardiac hypertrophy.