Consistent with the finding that G3BP1 knockdown increased gastric cancer sensitivity to chemotherapy, depletion of G3BP1 substantially increased the apoptosis level in gastric cancer cell lines, including MGC80-3, HGC-27, SGC-7901 and BGC-823, as indicated by the Annexin V-FITC and PI labelling-based flow cytometry analysis (Fig. 3a, b and Supplementary Fig. 4a, b). The gene discussed is ANXA5; the disease is gastric cancer.