Based on the microarray or RNA-sequencing data, co-expression network analysis can be used to construct networks of genes with tendencies to be co-activated in the same biological processes; these networks can then be used to identify genes with regulatory roles in disease and their correlations with one another.39 Here, we found that in human gastric cancer, YWHAZ was the essential gene co-expressed with G3BP1 and that it was involved in both anti-apoptosis and drug resistance. The gene discussed is YWHAZ; the disease is gastric cancer.