Cancer cells, exposed to the conditions of hypoxia, nutrient starvation or chemotherapy-induced high reactive oxygen species, are expected to promote eukaryotic initiator factor 2A phosphorylation-triggered SGs assembly.36 In addition, it has been established that SGs act as storage sites for non-translating mRNAs separated from disassembled polysomes;13 thus, G3BP1, an essential component of SGs, might also be involved in the regulation of apoptosis and the response to chemotherapy in gastric cancer, as investigated in this study. This evidence concerns the gene G3BP1 and cancer.