Fluoropyrimidine-based chemotherapy (5-fluorouracil, capecitabine or S-1) and platinum-based drugs (cisplatin or oxaliplatin) are the first-in-class chemo-drugs for advanced gastric cancer treatment.22 They function by disrupting normal RNA processing and function23 or by activating the DNA damage response and the induction of mitochondrial apoptosis.24 Therefore, to further evaluate whether G3BP1 governs gastric cancer chemoresistance, we examined G3BP1 function in gastric cancer cells following capecitabine and oxaliplatin treatments. Here, G3BP1 is linked to gastric cancer.