We compared the expression levels of DHPS with responses to more than 297 drugs across 169 lung cancer cell lines (Supplementary Table 2); DHPS expression correlated negatively with cellular sensitivity to inhibitors of EGFR, BRAF, or MEK1/2 (Fig. 5b, c and Supplementary Fig. 3), indicating that high DHPS expression renders these cells and tumors more resistant to kinase inhibitors that target this pathway. This evidence concerns the gene DHPS and lung cancer.