Moreover, analysis of bulk microarray data from mouse models of amyloid-beta deposition or Tau hyperphosphorylation also revealed transcriptome reprogramming similar to that observed in endothelial cells in patients with AD (SI Appendix, Fig. S7E), suggesting that the activation of endothelial cells in neurodegeneration is conserved between humans and mice. This evidence concerns the gene MAPT and Alzheimer disease.