CTLA4 and neoplasm: In addition, the combination of SB-3CT and anti-CTLA-4 to treat this mouse model tumor (Additional file 1: Fig. S9B) showed similar results that substantially inhibited lung metastasis (Fig. 7g, h) and extended the survival time of the mice with tumor metastasis to the lungs (62 days vs 19 days; p < 0.01; Fig. 7i).