Interestingly, this score significantly correlated with many cancer hallmarks associated with immune response, including TNF-α signaling via NF-κB, IL2, and STAT5 signaling; IL6, JAK, and STAT3 signaling; inflammatory responses; IFNα response; and IFNγ response (Additional file 1: Fig. S1C). The gene discussed is TNF; the disease is cancer.