This study found that the expression of local ANGPTL2 in the ovarian tissues of rats in the PCOS group was abnormally increased, which might subsequently aggravate IR, promote PI3K phosphorylation, increase FOXO1phosphorylation, down-regulate apoptotic gene expression, and induce follicular atresia, causing PCOS. Here, ANGPTL2 is linked to polycystic ovary syndrome.