In fact, ALS shares many pathological features as well as genetic risk factors with frontotemporal dementia (FTD), which like ALS is associated with mutations in and aggregates of TDP-43, and these diseases are considered to be part of the same ‘disease continuum’ of TDP-43 proteinopathies [69]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.