In TDP-43-associated ALS, for example, there is splicing defect-associated loss of the survival factor stathmin-2 (STMN2), a microtubule-destabilizing factor essential for axonal microtubule integrity, resulting in impairment of neurite growth and neuronal repair after injury [255]. This evidence concerns the gene STMN2 and amyotrophic lateral sclerosis.