NFE2L2 and hypertensive disorder: In addition, mice with DJ-1 selectively silenced in the kidney, and mice with germline deletion of DJ-1 (DJ-1−/− mice), develop high blood pressure, renal damage and decreased kidney expression and activity of Nrf2 [20], suggesting that DJ-1 inhibits the production of renal reactive oxygen species (ROS), at least in part, via the activation of Nrf2-controlled antioxidant genes.