Further studies of the pathways involved led to the conclusion that during the proliferation and growth of HCC cells, STIM1 is expressed at a high level, leading to enhanced store-operated Ca2+ entry and activation of the CamKII/Akt/Gsk3β pathway which, in part, maintains expression of transcription factor Snail1 at a low level. The gene discussed is AKT1; the disease is hepatocellular carcinoma.