Studies employing HCC cell lines showed that knockdown of mitochondrial Ca2+ uniporter regulator 1 and the associated decreased mitochondrial and cellular production of ROS, led to decreased invasion and migration, increased expression of epithelial cell markers (ZO-1 and E- cadherin), decreased expression of mesenchymal markers (N- cadherin and vimentin) and decreased expression of the transcription factor snail, a regulator of the epithelial mesenchymal transition [105]. This evidence concerns the gene SNAI1 and hepatocellular carcinoma.