In particular, these miRNAs could act as complex that regulates the response to nCRT by targeting genes associated with CRC, including the gene mutated in colorectal cancers (MCC), the gene interleukin-6 signal transducer (IL6ST), and the gene cell cycle checkpoint kinase 2 (CHEK2), as well as the gene marker of proliferation Ki67 (MKI67) [73]. The gene discussed is IL6ST; the disease is colorectal carcinoma.