Accordingly, Slattery and colleagues evaluated differences in the expression of miRNAs by comparing a total of seventy colon and rectal tissues with specific tumor alterations (i.e., C phosphate G (CpG) island methylator phenotype positive (CIMP+), microsatellite instability positive (MSI+), Kirsten rat sarcoma viral oncogene (KRAS2)-mutated and tumor protein 53 (TP53)-mutated and 30 normal tissues obtained from paraffin-embedded tissues, by using a microarray approach [51]. Here, KRAS is linked to neoplasm.