Other mutated genes had a mutation frequency <3% and include classical cancer related genes (KRAS, SMAD4, PDGFRB, KIT, APC, ERBB2, AR, MSH3 and LAMA1), assembly and disassembly of chromosomes (ATM, MEN1, FANCD2, KAT6B, RAD51C, PARP1, KMT2C, HECW2, BAP1 and POLE) and signal transmission (ROS1, EPHA3, FLT). The gene discussed is APC; the disease is cancer.