Mutations less than 10% comprehend also classical lung cancer related genes (EGFR, PDGFRA, NF1, KRAS, NTRK3, APC, GNAS, KDR, ERBB4 and EPHA5) and regulation of cellular processes (ERBB2, FGFR1, FLT4, RET, KIT, PTEN, PIK3CA, KDR, EPHB1, NOTCH2, TNFAIP3, AR, PTPRT, SMO, PTCH1, DICER1, PTPRZ1, CSMD3 and MDM4). This evidence concerns the gene PTCH1 and lung cancer.