SMAD4 and cancer: Other mutated genes had a mutation frequency <3% and include classical cancer related genes (KRAS, SMAD4, PDGFRB, KIT, APC, ERBB2, AR, MSH3 and LAMA1), assembly and disassembly of chromosomes (ATM, MEN1, FANCD2, KAT6B, RAD51C, PARP1, KMT2C, HECW2, BAP1 and POLE) and signal transmission (ROS1, EPHA3, FLT).