PTGS2 and neoplasm: Inhibition of cyclooxygenase 2 (COX-2) in this model reduced polyp size and mediated a change of macrophage polarization towards M1-like macrophages in an IFNγ-dependent manner, underlining the anti-tumor effects of M1-like macrophages and pro-tumorigenic effects of M2-like macrophages in intestinal tumorigenesis [130].