TBC1D24 and deafness: Surprisingly, in two affected members of family PKDF1429 (Figure 1) a compound heterozygous genotype resulted in deafness with seizure, while for the same compound heterozygous genotype the other two siblings in this family have non-syndromic deafness DFNB86. A common phenomenon for variants of TBC1D24 is that phenotype varies depending upon the second pathogenic variant in trans.