TGFBR3 and sickle cell disease: Furthermore, besides above-mentioned relationship between SNPs of the TGFBR3 gene and neoplastic transformation, the importance of polymorphism in betaglycan encoding gene was reported for other non-cancerous diseases, i.e., premature ovarian failure (POF), testicular dysgenesis, sickle cell anemia, pulmonary emphysema and primary open angle glaucoma [46,47,48,49,50,51].