Literature data and our previous studies indicate the contribution of betaglycan loss to the development and progression of cancers originated from different tissue types, i.e., breast, endometrium, ovary, prostate, lung, bladder, liver, pancreas, kidney, and neuroblastoma [17,18,19,20,21,22,23,24,25,26,27,28]. This evidence concerns the gene TGFBR3 and cancer.