The rs12566180 (c.-114 + 2392C > T) and rs2296621 (c.2285 − 99G > T) polymorphisms significantly altered in endometrial cancer are located within intronic regions of the TGFBR3 gene, which may indicate their potential impact on transcription and stability of the primary transcript. This evidence concerns the gene TGFBR3 and endometrial cancer.