INS and type 2 diabetes mellitus: Univariate analyses of the associations between AUCsRAGE 0–240 and AUC0–240 for glucose and the glucose regulating hormones insulin, glucagon, GLP-1, and GIP showed strong negative relationships between sRAGE and GLP-1 in individuals with type 2 diabetes, both during OGTT and IIGI at the 75 g dose (Table 3).