Altogether, these results were in line with our earlier observations that shRNA-mediated knockdown of HSPA2 expression did not affect the proliferation, metabolic activity, and clone-forming ability of two cell lines originating from NSCLC, namely NCI-H23 (adenocarcinoma, arising from bronchial mucosal gland) and NCI-H1299 (derived from the metastatic tumor) [18]. This evidence concerns the gene HSPA2 and adenocarcinoma.