CLDN6 and metastatic malignant neoplasm in the lymph nodes: In the present study, we demonstrated that high CLDN6 expression in endometrial cancer tissues, in which the strong and moderate signal intensity (SI) on cell membranes was observed at greater than 30% and 50%, respectively, was significantly related to several clinicopathological features such as surgical stages III/IV, histological type, histological grade 3, LVSI, lymph node metastasis and distant metastasis.