These TPH values overlapped with the range observed in: 217 healthy donors by Kremers et al. [33] (1 pM TF triggered PFP, TPH range: 41–371 nM), in severe-to-mild hemophilia donors described by van Veen et al. [34] (TPH 9–107 nM), and in patients with at least one thrombotic event and a confirmed diagnosis of inherited thrombophilia from Luna-Záizar et al. [35] (5 pM TF triggered PFP, TPH range: 21.8–499.3 nM). This evidence concerns the gene PRF1 and hemophilia.