PDE6B and retinitis pigmentosa 1: TUDCA has been shown to be neuroprotective in treatment of patients with amyotrophic lateral sclerosis [200] and preserved photoreceptor function in rd10 and rd1 mouse models of RP, Bardet–Biedl syndrome (Bbs1) mice [201,202,203] and RhoP23H rat models [187,204].