Interestingly, different cellular and soluble components of the bone marrow microenvironment cooperatively enhance PIM2 expression in MM cells, thus promoting antiapoptotic effects [4], and PIM2 is also required for maintaining myeloma cell growth through modulating TSC2 phosphorylation, a negative regulator of mTORC1 [5]. The gene discussed is PIM2; the disease is Miyoshi myopathy.