CD38 and Schnyder corneal dystrophy: In order to gain additional insight regarding hematopoiesis in SCD, we quantified the 9 populations depicted in Figure 1A. These populations include the myeloid progenitor compartment defined as a population of Hematopoietic Progenitor Cells (HPCs, Lin−CD34+CD38−) which encompasses the CMPs, GMPs, MEPs, and the stem cell compartment defined as a population of Hematopoietic Multipotent Cells (HMCs, Lin−CD34+CD38+), which encompasses the 49f, HSCs, MPPs, and LMPPs.