In this regard, CXCL1 can activate VEGF signaling in gastric tumor cells [212] and CXCL8 activation of CXCR2 increased VEGF mRNA expression in cultured endothelial cells [213], suggesting a relation between proangiogenic chemokines, produced in response to IL-17A, and VEGF expression. This evidence concerns the gene VEGFA and gastric neoplasm.