NCOA7 and ovarian dysfunction: Notably, we found that oxr1a gene has significant homology with ncoa7 in genomic structure and conserved domains, suggesting that it may has a conservative function for oxr1a in antioxidant protection during ovulation; thus, the premature ovarian failure of oxr1a−/− mutant zebrafish is most likely caused by the loss of oxr1a increasing oxidative damage to the ovary.