Additionally, in adolescents with varicocele, the same group reported an increase in SP levels of insulin-like growth factor-binding protein 7 (IGFBP7), a protein related to cell differentiation and proliferation, and a decrease in deoxyribonuclease-1 (DNase I), responsible for apoptosis regulation, particularly in patients with varicocele and altered semen analysis [121]. Here, IGFBP7 is linked to varicocele.