For example, two POT1 germline mutations (p.Gly95Cys and p.Glu450*) were identified among one cohort of familial glioma cases (3.6%, n = 2/55), and an additional germline variant (p.Asp617Glufs) was discovered in another cohort (0.4%, n = 1/246) [96]. The gene discussed is POT1; the disease is glioma.