A number of groups such as the Telomeres Mendelian Randomization Collaboration [126] have analyzed genomic variants associated with telomere length at various loci, including POT1 [127], and have reported causal relationships between longer telomeres and the risk of cancers, including the following: melanoma, glioma, non-small-cell lung, serous ovarian, bladder, testicular germ cell, renal and endometrial [126]. This evidence concerns the gene POT1 and central nervous system cancer.