Intriguingly, the downregulation of POT1 expression may contribute to the oncogenic role of Epstein–Barr Virus (EBV) in Hodgkin’s lymphoma: an EBV protein, Latent Membrane Protein 1 (LMP1), has been reported to downregulate three shelterin proteins by transcriptional and translational mechanisms and to cause the aggregation of telomeres and multinucleation [125]. This evidence concerns the gene POT1 and Hodgkins lymphoma.