The association of risk of CLZ-induced myocarditis/cardiomyopathies with rapid titration or VPA administration at the commencement of CLZ [50] are explained in that the increased Cx43 in cytosol in cardiac cells is drastically trafficked to the plasma membrane resulting in the toxic hyperfunction of Cx43-associated hemichannels and gap-junctions. The gene discussed is GJA1; the disease is cardiomyopathy.