Indeed, zonisamide and lacosamide, which clinically suppressed carbamazepine-resistant epileptic seizure of sleep-related hypermotor epilepsy, reduced Cx43 expression and its function, respectively [103,105,106], whereas the anticonvulsive target of carbamazepine in astrocytes was not Cx43 [103,146]. The gene discussed is GJA1; the disease is familial sleep-related hypermotor epilepsy.