Overexpression of SLFN12 significantly reduced mRNA levels of the adenocarcinoma differentiation marker SCGB1A1 in all of the LUAD cells studied (HCC827, H23, and H1075) and in one LUSC cell line (H2170 cells) compared with treatment with AdCMV as a control. Here, SLFN12 is linked to adenocarcinoma.