Next, because SLFN12 regulates ZEB1 in breast cancer through translational inhibition [12], and CDX2 in intestinal epithelial cells by modulating the deubiquitylases USP14 and UCHL5 [11], we decided to separately inhibit the proteasome and UCHL5/USP14 deubiquitylase activity to determine if either would block the ability of SLFN12 to reduce c-myc protein. The gene discussed is USP14; the disease is breast carcinoma.