Of note, 2 of 4 1α,25(OH)2D3 -treated control mice exhibited severe hyperphosphatemia (>30 mg/dL), whereas 1α,25(OH)2D3 did not induce hyperphosphatemia in any of the Ob-VDR-cKO mice (Fig. 5B). Here, VDR is linked to hyperphosphatemia.