AKT1 and nonpapillary renal cell carcinoma: Nuclear HIF expression, elevated expression of Ubiquitin Protein Ligase E3C (UBE3C), reduced expression of phos‐Akt in the nucleus and CAIX and loss of p27 expression are reported as significant independent prognostic factors for poor ccRCC outcomes.83, 84, 85, 86, 87