Nuclear HIF expression, elevated expression of Ubiquitin Protein Ligase E3C (UBE3C), reduced expression of phos‐Akt in the nucleus and CAIX and loss of p27 expression are reported as significant independent prognostic factors for poor ccRCC outcomes.83, 84, 85, 86, 87. The gene discussed is UBE3C; the disease is nonpapillary renal cell carcinoma.