We next evaluated the impact of HCMV infection on SAMHD1 localization, with the rationale that the inability of SAMHD1 to restrict HCMV replication may relate to a viral evasion mechanism that altered the nuclear localization of SAMHD1, which contains a classic nuclear localization signal (NLS). The gene discussed is SAMHD1; the disease is cytomegalovirus infection.