CXCR1 and its ligand C-X-C motif chemokine ligand 8 (CXCL8)/interleukin 8 (IL-8) have been reported in multiple fish species [63] and fish CXCL8/IL-8 is also induced in spleen upon infection with VHSV [64] and IHNV [46]. Here, CXCL8 is linked to infection.