Single nucleotide polymorphisms (SNPs) may affect the expression of IGF-1, AKT, and FOXO. One prior study pointed out that SNP rs35767 affects circulating IGF-1 levels, showing that white European adults without diabetes who carried GG genotype of the rs35767 polymorphism, which is located in IGF-1 promoter region, were associated with lower IGF-1 level compared with A allele carriers [21]. The gene discussed is IGF1; the disease is diabetes mellitus.