ARHGEF28 and hearing loss disorder: These hair cell-specific risk genes included known hearing loss genes such as Triobp (p = 9.5x10-42) and Eya4 (p = 2.3x10-21), as well as genes that have not previously been implicated in human hearing loss; e.g., Baiap2l2 (p = 2.6x10-192; Fig 5E), Arhgef28 (p = 9.8x10-31; Fig 5C), Gnao1 (p = 4.1x10-29), Rpgrip1l (p = 6.3x10-24), and Crip3 (p = 9.1x10-21).