The mice infection with a parasite isolated from a patient with digestive form of the disease led to an increasing in the jejunum wall thickness in both NOD2-/- and C57BL/6 infected mice, when compared to uninfected controls (Fig 4N), but the jejunum wall thickness in NOD2-/- infected animals was bigger when compared with C57BL/6 infected mice (Fig 4I, 4L and 4N). Here, NOD2 is linked to infection.