Probably, the IgA acts with mucosal immunity neutralizing intracellular viruses (Gonçalves et al., 2014) and preventing viral particles from infecting the cervical basal cell layer in the transformation zone (Pinto et al., 2018) and, as reported by Monroy et al., after natural infection, anti-HPV-IgA antibodies are detectable in the cervix, especially in persistent HPV infections (Monroy et al., 2010). This evidence concerns the gene CD79A and infection.