In this study, we aimed to investigate the relationship between eight single nucleotide polymorphisms (SNPs) in five selected proinflammatory and immune-mediated genes (TNF rs1800629G>A, rs361525G>A, rs1799964T>C, LTA rs1800683G>A, rs909253A>G, TNFAIP8 rs1042541C>T, LEPR rs1327118G>C, and LEP rs2167270G>A) and the risk and overall survival of DLBCL patients in the Jordanian Arab population. This evidence concerns the gene TNF and diffuse large B-cell lymphoma.