The CXC family of chemokines and their receptors, especially CXCR3 with their ligands CXCL9, CXCL10, and CXCL11 are involved in tumor and metastatic development through overexpression of CXCR3 in tumor cells which causes an excessive response to the expression of chemokines in tumors and inflammatory cells (Monteagudo, et al. , 2007). This evidence concerns the gene CXCR3 and neoplasm.