Moreover, PTEN inhibits metastasis in breast cancer cells through the downregulation of WNT1 inducible signaling pathway protein 1 (WISP1) and lipocalin-2 (LCN2) (Chiang et al., 2016), and inactivation of NFkB signaling in non-small cell lung cancer cells (Akgun et al., 2019). The gene discussed is CCN4; the disease is non-small cell lung carcinoma.