TNFSF11 and arthritic joint disease: Brazilin was also found to decrease the expression of TNFα in mice with type-II collagen-induced arthritis (Jung et al., 2015) and to decrease the expression of COX2 and TNFα, and inhibit ERK/NFkB signaling in RANKL-stimulated RAW264.7 cells (Kim et al., 2015).