Brazilin was also found to decrease the expression of TNFα in mice with type-II collagen-induced arthritis (Jung et al., 2015) and to decrease the expression of COX2 and TNFα, and inhibit ERK/NFkB signaling in RANKL-stimulated RAW264.7 cells (Kim et al., 2015). The gene discussed is NFKB1; the disease is arthritic joint disease.