Since Fyn and Bat3 bind to the same domain of the Tim-3 cytoplasmic region resulting inhibition and activation of Tim-3 signaling, respectively, so the mRNA expression results were analyzed to find any correlations between Fyn and Bat3 mRNA expression with the expression of Tim-3 in CLL patients. Here, HAVCR2 is linked to B-cell chronic lymphocytic leukemia.