Among these co-inhibitory molecules, PD-1, and Tim-3 are two crucial immune checkpoint molecules which have been already established as the main T-cell exhaustion markers in several chronic pathological conditions including various types of solid and hematological malignancies (Sakuishi et al., 2010; Zhou et al., 2011; Llaó Cid et al., 2020). Here, HAVCR2 is linked to hematologic disorder.