Fyn expression is up-regulated in several solid tumors, including glioblastoma, head and neck squamous cell carcinoma, melanoma, pancreatic, prostate cancer, and squamous cell carcinoma (Ayli et al., 2008; Ban et al., 2008; Zhao et al., 2009; Yadav and Denning, 2011). Here, FYN is linked to head and neck squamous cell carcinoma.