Several studies examined the association between IL-27 polymorphisms and the risk of various cancer (Wei et al., 2009; Zhao et al., 2009; Guo et al., 2012; Huang et al., 2012; Pan et al., 2012; Tao et al., 2012; Peng et al., 2013; Munretnam et al., 2014; Tang et al., 2014; Zhang et al., 2014a; Zhang et al., 2014b; Lyu et al., 2015; Pu et al., 2015; Zhang et al., 2015; Zhou et al., 2015; Ge and Xiao, 2016; Wang et al., 2016; Yu et al., 2016; Nie et al., 2017; Ghavami et al., 2018). Here, IL27 is linked to cancer.