The frequency of CSCs CD133+ appears to be variable among OSCCs and Head and Neck Squamous Cell Carcinoma (HNSCCs) with cases of low (Wang et al., 2016; de Moraes et al., 2017) and high cell CD133+ expression (Ravindran and Devaraj, 2012; Liu et al., 2013; Manelli et al., 2015). This evidence concerns the gene PROM1 and head and neck squamous cell carcinoma.