PROM1 and cancer: CD133 consists of an N-terminal extracellular domain, five transmembrane domains, and an intracellular cytoplasmic tail with functional tyrosine kinase sites (Udeabor et al., 2012), which will interact with distinct cytoplasmic partners, regulating signal molecules and changing the cancer metabolism, thus promoting the CSC properties (Jang et al., 2017).