The first-line therapy is surgical removal of the pituitary GH-secreting adenoma, which normalises GH/IGF-I levels in 40–70% of patients [5–8], depending on tumour size (microadenomas are more amenable to cure), preoperative GH concentration (the success rate is higher when GH concentrations are low, i.e., <10 μg/L or 30 mIU/L) and surgeon experience. This evidence concerns the gene IGF1 and neoplasm.