Using the same adult sample reported here, this task has been found to be one of the most sensitive tasks associated with cognitive decline in adults with DS.2 In the present study, we detected diverging trajectories on this task based on APOE status, consistent with the onset of AD brain pathology in individuals with DS in their 30s.1 Thus, our results are in line with findings that the APOE ε4 genotype is associated with an earlier and faster progression of AD.2,3. The gene discussed is APOE; the disease is Alzheimer disease.