Notably, the coexistence of different misfolded proteins has been reported to occur in individual patients; specifically, some brains with neuropathologically confirmed AD, PSP, and CBD were reported to contain Lewy bodies concurrent with deposits of β-amyloid and/or tau.47,48,49,50,51 Thus, it would be important to examine both the brain and skin tissues of these individuals to determine whether the 2 types of tissues are consistent in having αSynP seeding activity.52 Here, MAPT is linked to Alzheimer disease.