In addition to regulating Lin28, let‐7 miRNAs directly target and repress the expression of Irs2 (Zhu et al, 2011), a positive regulator of cell proliferation upregulated in liver, pancreas, and prostate cancer (Mardilovich & Shaw, 2009; Mardilovich et al, 2009). The gene discussed is LIN28A; the disease is Familial prostate cancer.