IRS2 and cancer: Among the top 5% of DEGs most significantly changed, we found Prtg, Lin28, Greb1, and Irs2 (Fig 4E), known as positive regulators of cell proliferation upregulated in cancer (Wong et al, 2010; Stamateris et al, 2016; Farzaneh et al, 2017; Hodgkinson et al, 2018).