By exploiting the recent development of fast and highly efficient multidimensional inverse Laplace decomposition algorithm7,30, unique two-dimensional signature of various hemoglobin (Hb) derivatives with respect to its magnetic resonance relaxation reservoirs in oxygenated (oxy-Hb), deoxygenated (deoxy-Hb) and oxidized (oxidized Hb) states were observed for the first time (to the best of our knowledge) and its phenotypic expression in various pathological states (e.g., blood oxidation, hemoglobinopathies) are reported in this work. The gene discussed is GSTM1; the disease is hemoglobinopathy.