Many signaling pathways and oncoproteins, including AKT, p21, NF-kB, c-myc, and β-catenin have established roles in migration and EMT progression of TNBC cells; (1) activation of NF-kB signaling stimulates an aggressive phenotype of breast cancer cells through the transcriptional activation of EMT regulatory genes. The gene discussed is AKT1; the disease is breast cancer.