Silencing of p21 gene caused the inhibition of tumor invasion in a mammary fat pad xenograft mouse model and in various breast cancer cell lines52; (3) activated AKT signaling represents one of the most commonly observed dysregulations in breast cancer and has established roles in migration and metastasis of TNBC cells making inhibition of AKT an attractive therapeutic target53,54. The gene discussed is AKT1; the disease is breast cancer.