IGF1 and breast cancer: For instance, Evdokimova et al.26 was the first to demonstrate that Akt-mediated phosphorylation of YB-1(YBX1) at S102 precluded binding of YBX1 to mRNA thereby relieving translational repression of oncogenes such as Insulin-like growth factor 1 (IGF-1), Vascular endothelial growth factor (VEGF) and Fos Proto-Oncogene (FOS) in breast cancer cells.